![]() Results PARP inhibitors, KU-0058948 and PJ34, induced cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro. Design and Methods Leukemic cell lines were exposed to various PARP inhibitors alone and in combination with non-cytotoxic concentrations of DNA methyltransferase inhibitor, 5’ aza-2’-deoxycytidine and/or the histone deacetylase inhibitor, MS275, to test for potentiation of apoptosis with these agents. ![]() Since poly (ADP-ribose) polymerase (PARP) inhibitors have been recently shown to selectively target cells with defects in double-strand DNA repair, the aim of this study was to explore the possibility of exploiting defects in DNA repair in leukemic cells using PARP inhibitors. Posted on 9 Categories Miscellaneous Tags DASS-GUI, Non-sequential Data, Pattern Search Leave a comment on DASS-GUI 1.4 – Pattern Search in Non-sequential Data PrestoPlot 1.Abstract Background Aberrant or impaired repair of double-strand DNA breaks is a common feature of de novo acute myeloid leukemia and myelodysplastic syndromes. (2010)ĭASS-GUI: a user interface for identification and analysis of significant patterns in non-sequential data.īioinformatics 26(7), 987-9. Hollunder, J., * Friedel, M., Kuiper, M., Wilhelm, T. DASS-GUI also allows additional analyses of the identified closed sets: filtering, handling of synonymous names, enrichment analyses, calculation of means and standard deviations of different numerical features, extraction of the underlying closed set hierarchy and corresponding export as GML file, as well as comparison (validation) with pre-defined sets. Some of the used algorithms are taken from Hollunder et al. ![]() In addition, it has several features for predicting protein coding regions in sequences searching and including Pubmed references in Repbase entries and searching the NCBI taxonomy database for correct inclusion of species information and taxonomic position.Īnnotation, submission and screening of repetitive elements in Repbase: RepbaseSubmitter and Censor.īMC Bioinformatics, 2006 Oct 25 7:474 Posted on 9 8 Categories Miscellaneous Tags Annotate, ENTRY, format, Repbase, Repbase Submitter Leave a comment on Repbase Submitter 1.1.115 – Format & Annotate Repbase Entries DASS-GUI 1.4 – Pattern Search in Non-sequential DataĭASS-GUI is a stand-alone program written in C++ that calculates all significant closed sets* of a given dataset containing the host sets. ![]() It eliminates many common formatting errors, and automates actions such as calculation of sequence lengths and composition, thus facilitating curation of Repbase sequences. RepbaseSubmitteris a java-based interface for formatting and annotating Repbase entries. ![]()
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